trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol

Base Information

• Chemical Name: trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol
• CAS No.: 422507-07-1
• Molecular Formula: C₁₈H₂₇NO₃
• Molecular Weight: 305.417
• Mol file: 422507-07-1.mol

Synonyms:trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol

Chemical Property of trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol

There total 2 articles about trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl N-benzyl(4-oxocyclohexyl)carbamate (188562-91-6) → trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol (422507-07-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 4h;

DOI:10.1021/jo0163849

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-trans-4-aminocyclohexanol (162338-03-6) → trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol (422507-07-1)

Guidance literature:

With potassium carbonate; triethylamine; In chloroform; at 0 - 20 ℃;

DOI:10.1055/s-0029-1216989

Reference yield: 63.0%

trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol (422507-07-1) → 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene (422507-09-3)

Guidance literature:

trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol; With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 18h; Reflux;

DOI:10.1055/s-0029-1216989

upstream raw materials:

tert-butyl N-benzyl(4-oxocyclohexyl)carbamate

di-tert-butyl dicarbonate

N-benzyl-trans-4-aminocyclohexanol

Downstream raw materials:

4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene

N-benzyl-N-(3-cyclohexenyl)amine

4-[N-benzyl-N-(methoxycarbonylmethyl)amino]-1-cyclohexene

4-{benzyl-[2-(methylselanyl)-2-oxoethyl]amino}cyclohex-1-ene