1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

Base Information

Chemical Name:1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one
CAS No.:1373243-38-9
Molecular Formula:C₃₀H₂₅NO₅
Molecular Weight:479.532
Hs Code.:

Synonyms:1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

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Chemical Property of 1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

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Technology Process of 1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

There total 4 articles about 1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1373243-37-8
1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

: 1373243-38-9
1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

Guidance literature:: 1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate; With water; sodium hydroxide; In methanol; at 20 ℃; for 5h;

With hydrogenchloride; In methanol; water; at 0 ℃; pH=7;

Reference yield:

: 1221748-96-4
1'-(diphenylmethyl)-6-hydroxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

: 1373243-38-9
1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 20 °C

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 48 h / 0 - 20 °C

4.1: sodium hydroxide; water / methanol / 5 h / 20 °C

4.2: 0 °C / pH 7

With aluminum (III) chloride; water; sodium hydride; acetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: Baeyer-Villiger Oxidation;

Reference yield:

: 1373243-15-2
5-acetyl-1'-benzhydryl-6-hydroxy-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-38-9
1'-benzhydryl-5-hydroxy-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 20 °C

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 48 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 5 h / 20 °C

3.2: 0 °C / pH 7

With water; sodium hydride; acetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: Baeyer-Villiger Oxidation;