1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

Base Information

Chemical Name:1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate
CAS No.:1373243-37-8
Molecular Formula:C₃₂H₂₇NO₆
Molecular Weight:521.569
Hs Code.:

Synonyms:1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

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Chemical Property of 1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

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Technology Process of 1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

There total 3 articles about 1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1373243-36-7
5-acetyl-1'-benzhydryl-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-37-8
1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

Guidance literature:: 5-acetyl-1'-benzhydryl-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one; With acetic acid; In dichloromethane; for 0.5h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 48h;

Reference yield:

: 1221748-96-4
1'-(diphenylmethyl)-6-hydroxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

: 1373243-37-8
1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 20 °C

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 48 h / 0 - 20 °C

With aluminum (III) chloride; sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: Baeyer-Villiger Oxidation;

Reference yield:

: 1373243-15-2
5-acetyl-1'-benzhydryl-6-hydroxy-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-37-8
1'-benzhydryl-6-(methoxymethoxy)-2'-oxo-2H-spiro[benzofuran-3,3'-indolin]-5-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 20 °C

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 48 h / 0 - 20 °C

With sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: Baeyer-Villiger Oxidation;