1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

Base Information

Chemical Name:1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one
CAS No.:1373243-41-4
Molecular Formula:C₃₁H₂₃NO₄
Molecular Weight:473.528
Hs Code.:

Synonyms:1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

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Chemical Property of 1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

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Technology Process of 1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

There total 5 articles about 1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373243-39-0
1'-benzhydryl-6-(methoxymethoxy)-5-(prop-2-yn-1-yloxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-41-4
1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C

2: triethylamine; copper(l) iodide / 1.5 h / 20 - 100 °C

With copper(l) iodide; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1373243-15-2
5-acetyl-1'-benzhydryl-6-hydroxy-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-41-4
1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 20 °C

2.1: acetic acid / dichloromethane / 0.5 h

2.2: 48 h / 0 - 20 °C

3.1: sodium hydroxide; water / methanol / 5 h / 20 °C

3.2: 0 °C / pH 7

4.1: potassium carbonate / acetone / 1 h

4.2: 32 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C

6.1: triethylamine; copper(l) iodide / 1.5 h / 20 - 100 °C

With copper(l) iodide; water; sodium hydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil; 2.1: Baeyer-Villiger Oxidation;

Reference yield:

: 1373243-36-7
5-acetyl-1'-benzhydryl-6-(methoxymethoxy)-2H-spiro[benzofuran-3,3'-indolin]-2'-one

: 1373243-41-4
1'-benzhydryl-3-methylene-3,7-dihydro-2H-spiro[[1,4]dioxino[2,3-f]benzofuran-8,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / dichloromethane / 0.5 h

1.2: 48 h / 0 - 20 °C

2.1: sodium hydroxide; water / methanol / 5 h / 20 °C

2.2: 0 °C / pH 7

3.1: potassium carbonate / acetone / 1 h

3.2: 32 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C

5.1: triethylamine; copper(l) iodide / 1.5 h / 20 - 100 °C

With copper(l) iodide; water; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; acetone; 1.1: Baeyer-Villiger Oxidation;