Technology Process of 1-(4-(tert-butyl)-2,6-diiodophenyl)-3,3-diethyltriaz-1-ene
There total 2 articles about 1-(4-(tert-butyl)-2,6-diiodophenyl)-3,3-diethyltriaz-1-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(tert-butyl)-2,5-diiodoaniline;
With
hydrogenchloride; sodium nitrite;
In
tetrahydrofuran; diethyl ether; acetonitrile;
at -5 - 0 ℃;
for 1.5h;
diethylamine;
With
potassium carbonate;
In
tetrahydrofuran; diethyl ether; acetonitrile;
for 1.5h;
Further stages.;
DOI:10.1021/jo010183n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 72 percent / (BnEt3N)ICl2; CaCO3 / CH2Cl2; methanol / 40 °C
2.1: aq. HCl; NaNO2 / diethyl ether; tetrahydrofuran; acetonitrile / 1.5 h / -5 - 0 °C
2.2: 88 percent / aq. K2CO3 / acetonitrile; diethyl ether; tetrahydrofuran / 1.5 h
With
hydrogenchloride; calcium carbonate; benzyl triethylammonium dichloroiodate; sodium nitrite;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo010183n
- Guidance literature:
-
1-(4-(tert-butyl)-2,6-diiodophenyl)-3,3-diethyltriaz-1-ene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.833333h;
Inert atmosphere;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.202006087
