Technology Process of (4R,5S,6S,7R)-4,7-dibenzyl-1,3-bis[(2-fluorophenyl)methyl]-5,6-dihydro xy-1,3-diazepan-2-one
There total 6 articles about (4R,5S,6S,7R)-4,7-dibenzyl-1,3-bis[(2-fluorophenyl)methyl]-5,6-dihydro xy-1,3-diazepan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 0.5 h, 2.) CH2Cl2, -70 deg C, 2 h
2: 55 percent / VCl3*(THF)3, Zn / CH2Cl2
3: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C
4: 52 percent / H2 / 10percent Pd/C / ethyl acetate; methanol
5: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h
6: HCl / methanol; dioxane
With
hydrogenchloride; oxalyl dichloride; Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 55 percent / VCl3*(THF)3, Zn / CH2Cl2
2: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C
3: 52 percent / H2 / 10percent Pd/C / ethyl acetate; methanol
4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h
5: HCl / methanol; dioxane
With
hydrogenchloride; Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C
2: 52 percent / H2 / 10percent Pd/C / ethyl acetate; methanol
3: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h
4: HCl / methanol; dioxane
With
hydrogenchloride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571
