7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

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Chemical Name:7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid
CAS No.:868836-07-1
Molecular Formula:C₂₆H₄₄N₄O₅
Molecular Weight:492.659
Hs Code.:

Synonyms:7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

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Chemical Property of 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

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Technology Process of 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

There total 5 articles about 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.7%

: 868836-02-6
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid

: 868836-07-1
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

Guidance literature:: 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm0505009

Reference yield:

: 868835-94-3
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-aminobutylamine

: 868836-07-1
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76.5 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: 72.3 percent / aq. LiOH / tetrahydrofuran / 0 - 20 °C

3.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3.2: 75.7 percent / hydroxylamine / methanol; tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0505009

Reference yield:

: 868835-87-4
N-{4-[(N,N-dimethylamino)benzyl]butyl}phthalimide

: 868836-07-1
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanohydroxamic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaHCO₃; NaCl / CH₂Cl₂ / 12 h / Heating

2.1: 88.3 percent / hydrazine / methanol / 12 h / Heating

3.1: 76.5 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4.1: 72.3 percent / aq. LiOH / tetrahydrofuran / 0 - 20 °C

5.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / 0 °C

5.2: 75.7 percent / hydroxylamine / methanol; tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; sodium chloride; hydrazine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0505009