1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Base Information

Chemical Name:1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine
CAS No.:868835-91-0
Molecular Formula:C₂₆H₃₃N₃O₄
Molecular Weight:451.566
Hs Code.:

Synonyms:1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Suppliers and Price of 1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

There total 5 articles about 1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 868835-91-0
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Guidance literature:: N-{4-[(N,N-dimethylamino)benzyl]butyl}phthalimide; With sodium hydrogencarbonate; sodium chloride; In dichloromethane; water; at 0 ℃; for 0.5h;

di-tert-butyl dicarbonate; In dichloromethane; water; at 0 - 20 ℃; for 12.1667h; Heating / reflux;

Reference yield:

: 66917-06-4
N-(4-azidobutyl)phthalimide

: 868835-91-0
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethanol / 12 h / 1292.87 Torr

2.1: acetic acid / 1,2-dichloro-ethane / 0.33 h / 20 °C

2.2: 0.810 g / NaCNBH₃ / 1,2-dichloro-ethane; methanol / 12 h

3.1: aq. NaHCO₃; NaCl / CH₂Cl₂ / 12 h / Heating

With hydrogen; sodium hydrogencarbonate; acetic acid; sodium chloride; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm0505009

Reference yield:

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 868835-91-0
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-phthalimidobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaN₃ / dimethylformamide / 5 h

2.1: H₂ / Pd/C / ethanol / 12 h / 1292.87 Torr

3.1: acetic acid / 1,2-dichloro-ethane / 0.33 h / 20 °C

3.2: 0.810 g / NaCNBH₃ / 1,2-dichloro-ethane; methanol / 12 h

4.1: aq. NaHCO₃; NaCl / CH₂Cl₂ / 12 h / Heating

With sodium azide; hydrogen; sodium hydrogencarbonate; acetic acid; sodium chloride; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0505009