[[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate

Base Information

• Chemical Name: [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate
• CAS No.: 1253421-26-9
• Molecular Formula: C₂₉H₃₇ClO₇
• Molecular Weight: 533.062

Synonyms:[[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate

Chemical Property of [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate

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Technology Process of [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate

There total 1 articles about [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

desisobutyryl ciclesonide (161115-59-9) + phosgene (75-44-5) → [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate (1253421-26-9)

Guidance literature:

In tetrahydrofuran; toluene; at 20 ℃; for 2h;

Reference yield: 32.0%

[[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate (1253421-26-9) + carbonic acid 1-[3-aminomethyl-4-(di-tert-butoxyphosphoryloxy)phenyl]-2-[(tert-butoxycarbonyl)[6-(4-phenylbutoxy)hexyl]-amino]ethyl ester tert-butyf ester (1253421-29-2) → [5-[1-[(tert-butoxycarbonyl)oxy]-2-[(t-butoxycarbonyl)-6-(4-phenylbutoxy)hexylamino]ethyl]-2-di-tert-butoxyphosphonooxybenzyl]carbamic acid [[11β,16α]-[16,17-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypreqna-1,4-diene-3,20-dion-21-yl]ester (1253421-30-5)

Guidance literature:

With 1,2,2,6,6-pentamethylpiperidine; In acetonitrile; at 20 ℃;

Reference yield: 30.0%

[[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl] chloroformate (1253421-26-9) + carbonic acid (R)-[2-[tert-butoxycarbonyl-[6-(4-phenylbutoxy)hexyl]amino]-1-[4-(di-tert-butoxyphosphoryloxy)-3-hydroxymethylphenyl]ethyl]ester tert-butyl ester (1253421-33-8) → carbonic acid [5-[1(R)-[(t-butoxycarbonyl)oxy]-2-[t-butoxycarbonyl[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(di-tert-butoxyphosphoryloxy)benzyl]ester [[11β,16α]-[16,17-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl]ester (1253421-27-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 96h;

upstream raw materials:

desisobutyryl ciclesonide

phosgene

Downstream raw materials:

2-dimethylaminoethylcarbamic acid [[11β,16α]-[[((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl]]ester

carbonic acid [5-[1(R)-[(t-butoxycarbonyl)oxy]-2-[t-butoxycarbonyl[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(di-tert-butoxyphosphoryloxy)benzyl]ester [[11β,16α]-[16,17-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl]ester

[5-[1-[(tert-butoxycarbonyl)oxy]-2-[(t-butoxycarbonyl)-6-(4-phenylbutoxy)hexylamino]ethyl]-2-di-tert-butoxyphosphonooxybenzyl]carbamic acid [[11β,16α]-[16,17-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypreqna-1,4-diene-3,20-dion-21-yl]ester

C₇₈H₁₁₀N₃O₁₇P

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