1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

Base Information

Chemical Name:1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea
CAS No.:1229017-32-6
Molecular Formula:C₁₉H₂₅BrN₄O₂S
Molecular Weight:453.403
Hs Code.:

Synonyms:1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

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Chemical Property of 1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

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Technology Process of 1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

There total 6 articles about 1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 542-85-8
Ethyl isothiocyanate

: 2-(5-amino-2-propoxyphenyl)-5-bromo-6-isopropylpyrimidin-4(3H)-one hydrochloride

: 1229017-32-6
1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

Guidance literature:: With triethylamine; In ethanol; for 3h; Reflux;

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1229017-32-6
1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: pyridine; bromine / dichloromethane / 0.17 h / Cooling with ice

3: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

4: hydrogenchloride; iron / water / 1 h / Reflux

5: triethylamine / ethanol / 3 h / Reflux

With pyridine; hydrogenchloride; sulfuric acid; bromine; nitric acid; iron; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 63874-26-0
2-n-propoxybenzamidine

: 1229017-32-6
1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: pyridine; bromine / dichloromethane / 0.17 h / Cooling with ice

3: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

4: hydrogenchloride; iron / water / 1 h / Reflux

5: triethylamine / ethanol / 3 h / Reflux

With pyridine; hydrogenchloride; sulfuric acid; bromine; nitric acid; iron; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;