4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

Base Information

Chemical Name:4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide
CAS No.:1413060-53-3
Molecular Formula:C₂₄H₂₂FN₃O₄
Molecular Weight:435.455
Hs Code.:

Synonyms:4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

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Chemical Property of 4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

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Technology Process of 4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

There total 6 articles about 4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1413064-03-5
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-carbamoylfuran-3-yl)benzyl acetate

: 1413060-53-3
4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

Guidance literature:: With methanol; potassium carbonate; for 3.5h; Inert atmosphere;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1413060-53-3
4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 20 h / Reflux

2: N,N-dimethyl-formamide / 6 h / 105 °C

3: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

5: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere

6: potassium carbonate; methanol / 3.5 h / Inert atmosphere

With methanol; potassium phosphate; N-Bromosuccinimide; potassium acetate; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; N,N-dimethylethylenediamine; XPhos; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 93701-32-7
2,6-dibromobenzyl bromide

: 1413060-53-3
4-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-furan-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 6 h / 105 °C

2: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

4: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere

5: potassium carbonate; methanol / 3.5 h / Inert atmosphere

With methanol; potassium phosphate; potassium acetate; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; N,N-dimethylethylenediamine; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;