(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid

Base Information

• Chemical Name: (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid
• CAS No.: 1007096-37-8
• Molecular Formula: C₂₈H₂₈N₂O₅
• Molecular Weight: 472.541
• Mol file: 1007096-37-8.mol

Synonyms:(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid

Chemical Property of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-L-Lys(Bz)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid

There total 3 articles about (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(S)-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoate (1245942-37-3) → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid (1007096-37-8)

Guidance literature:

(S)-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoate; With water; calcium chloride; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 5h;

With acetic acid; In water; isopropyl alcohol;

DOI:10.1016/j.bmc.2010.06.035

Reference yield:

benzoic acid N-hydroxysuccinimide ester (23405-15-4) + 9-fluorenylmethoxycarbonyl-L-alanine hydrochloride (139262-23-0) → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid (1007096-37-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

benzoic acid (65-85-0,8013-63-6) → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoic acid (1007096-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / dichloromethane / 24 h / 20 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(S)-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-benzamidohexanoate

benzoic acid N-hydroxysuccinimide ester

9-fluorenylmethoxycarbonyl-L-alanine hydrochloride

benzoic acid

Downstream raw materials:

(S)-methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-benzamidohexanamido)propanoate