2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol

Base Information

• Chemical Name: 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol
• CAS No.: 852837-09-3
• Molecular Formula: C₂₁H₃₃NO₂
• Molecular Weight: 331.499
• Mol file: 852837-09-3.mol

Synonyms:2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol

Chemical Property of 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol

There total 3 articles about 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

allylmagnesium bromide (2622-05-1) + benzoic acid 2-(4-chloromethyl-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl ester (216104-33-5) → 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol (852837-09-3)

Guidance literature:

In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1021/ja0422561

Reference yield:

4-Vinylbenzyl chloride (1592-20-7,29296-32-0) → 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol (852837-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / 20 h / 80 °C

2: 79 percent / tetrahydrofuran / 2 h / 60 °C

In tetrahydrofuran;

DOI:10.1021/ja0422561

Reference yield:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) → 2-[4-(but-3-enyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanol (852837-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / 20 h / 80 °C

2: 79 percent / tetrahydrofuran / 2 h / 60 °C

In tetrahydrofuran;

DOI:10.1021/ja0422561

upstream raw materials:

allylmagnesium bromide

benzoic acid 2-(4-chloromethyl-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl ester

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

4-Vinylbenzyl chloride

Downstream raw materials:

2-bromo-2-methyl-propionic acid 2-(4-but-3-enyl-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethyl ester

2-[4-(4-triethoxysilylbutyl)phenyl]-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethan-1-ol