2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:75948-76-4
Molecular Formula:C₁₇H₂₅NO₄S
Molecular Weight:339.456
Hs Code.:

Synonyms:2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

There total 6 articles about 2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75934-17-7
4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol

: 124-63-0
methanesulfonyl chloride

: 75948-76-4
2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With triethylamine; In dichloromethane; at -22 ℃;
DOI:10.1021/jo00317a027

Reference yield:

: 63667-83-4
1-(but-3-en-1-yl)-2-methoxybenzene

: 75948-76-4
2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1) TMEDA, n-BuLi / 1) in dry ether at reflux for 1h 2) CO₂ as a continous stream for 1h

2: 1) SOCl₂

3: 1) BF₃*THF 2) NaOH, H₂O₂ / 1) for 1h 2) at 50 deg C for 1h

4: 95 percent / triethylamine / CH₂Cl₂ / -22 °C

With sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; triethylamine; In dichloromethane;
DOI:10.1021/jo00317a027

Reference yield:

: 75934-25-7
3-(3-Butenyl)anisic Acid

: 75948-76-4
2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1) SOCl₂

2: 1) BF₃*THF 2) NaOH, H₂O₂ / 1) for 1h 2) at 50 deg C for 1h

3: 95 percent / triethylamine / CH₂Cl₂ / -22 °C

With sodium hydroxide; thionyl chloride; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; triethylamine; In dichloromethane;
DOI:10.1021/jo00317a027