N-Methylethylamine hydrochloride

Base Information

• Chemical Name: N-Methylethylamine hydrochloride
• CAS No.: 624-60-2
• Molecular Formula: C3H9N^.HCl
• Molecular Weight: 95.5721
• Hs Code.: 2921199090
• European Community (EC) Number: 210-854-8
• NSC Number: 7301
• DSSTox Substance ID: DTXSID00883512
• Mol file: 624-60-2.mol

Synonyms:624-60-2;N-Methylethylamine hydrochloride;N-methylethanamine hydrochloride;N-ethylmethylamine hydrochloride;Ethanamine, N-methyl-, hydrochloride;N-Methylethylamine, HCl;Ethyl(methyl)ammonium chloride;N-methylethanamine;hydrochloride;Ethylmethylamine hydrochloride;Methylethylammonium chloride;Ethanamine, N-methyl-, hydrochloride (1:1);NSC 7301;EINECS 210-854-8;ethyl(methyl)amine hydrochloride;Ethylamine, N-methyl-, hydrochloride;Methylethylamine hydrochloride;DTXSID00883512;NSC7301;NSC-7301;MFCD00051403;AKOS015894484;SB75367;CS-0158300;FT-0658670;N-Methylethylamine hydrochloride, AldrichCPR;EN300-64637;D78313;A833784;methylazanyliumylethane chloride;N-Ethylmethylamine HCl

Chemical Property of N-Methylethylamine hydrochloride

Chemical Property:

• Appearance/Colour: yellow adhering crystalline powder
• Vapor Pressure: 488mmHg at 25°C
• Melting Point: 126-130oC
• Refractive Index: 1,552
• Boiling Point: 36.7 °C at 760 mmHg
• PSA: 12.03000
• Density: 0.68 g/cm3
• LogP: 1.41860
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 95.0501770
• Heavy Atom Count: 5
• Complexity: 7.2

Purity/Quality:

99% ^*data from raw suppliers

N-MethylethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-36/37/38-36
• Safety Statements: 24/25-97-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC.Cl

Technology Process of N-Methylethylamine hydrochloride

There total 3 articles about N-Methylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-ethyl-N-methylbenzylamine (4788-37-8) → N-methyl-ethylamine hydrochloride (624-60-2)

Guidance literature:

With dichloromethane; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; atmospheric pressure;

DOI:10.1021/jo0480444

Reference yield: 66.0%

N-methyl-acetamide (79-16-3) → N-methyl-ethylamine hydrochloride (624-60-2)

Guidance literature:

N-methyl-acetamide; With tris(bis(trimethylsilyl)amido)lanthanum(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In benzene; at 25 ℃; for 72h; Inert atmosphere; Glovebox;

With hydrogenchloride; In methanol; at 0 ℃; Temperature;

DOI:10.1021/jacs.0c02446

Reference yield:

N-Nitroso-N-methyl-1-methoxyethylamine (61738-05-4) → N-methyl-ethylamine hydrochloride (624-60-2)

Guidance literature:

With hydrogenchloride; aluminum nickel; Yield given. Multistep reaction; 1.) 0.5 N aqueous KOH, 25 deg C, 1h;

DOI:10.1021/jo00162a019

upstream raw materials:

N-Nitroso-N-methyl-1-methoxyethylamine

N-ethyl-N-methylbenzylamine

N-methyl-acetamide

Downstream raw materials:

2-chloro-N-ethyl-8-(4-fluorophenyl)-7-(4-methoxybenzyl)-N-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine

2-chloro-N-ethyl-8-(4-fluorophenyl)-N-methyl-6,8-dihydro-5H-pyrano[3,4-d]pyrimidin-4-amine

2-chloro-N-ethyl-8-(4-fluorophenyl)-N-methyl-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine

rac-rivastigmine

Refernces

• 1、 Cheng, Chuanjie,Sun, Jianwei,Xing, Lixin,Xu, Jimin,Wang, Xinyan,Hu, Yuefei. "Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines". supporting information; experimental part. p. 5671 - 5674. Retrieved 2009/12/08.
• 2、 Saavedra, Joseph E.. "Lithiation of α-Nitrosaminoalkyl Ethers. Synthetic Equivalents of α-Primary Amino Carbanions". . p. 2388 - 2392. Retrieved 2007/10/02.