3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Base Information

Chemical Name:3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)
CAS No.:76991-46-3
Molecular Formula:C₃₂H₃₄Cl₄N₅O₁₁P
Molecular Weight:837.435
Hs Code.:

Synonyms:3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

There total 4 articles about 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 76991-45-2
5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

: 76991-46-3
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: With hydrazine hydrate; In pyridine; acetic acid; for 0.0666667h; Ambient temperature;
DOI:10.1021/jo00324a010

Reference yield:

: 71874-01-6
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine

: 76991-46-3
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / 2-chloro-1-methylpyridinium iodide, 1,4-diazabicyclo<2.2.2>octane / acetonitrile; dioxane / 2 h

2: 86 percent / 1-methylimidazole / acetonitrile / 0.75 h / 0 °C

3: 92 percent / hydrazine hydrate / pyridine; acetic acid / 0.07 h / Ambient temperature

With 1,4-diaza-bicyclo[2.2.2]octane; 1-methyl-1H-imidazole; 2-chloro-1-methyl-pyridinium iodide; hydrazine hydrate; In 1,4-dioxane; pyridine; acetic acid; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 59819-52-2
2,2,2-trichloroethyl 2-chlorophenyl phosphorochloridate

: 76991-46-3
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 1-methylimidazole / acetonitrile / 0.75 h / 0 °C

2: 92 percent / hydrazine hydrate / pyridine; acetic acid / 0.07 h / Ambient temperature

With 1-methyl-1H-imidazole; hydrazine hydrate; In pyridine; acetic acid; acetonitrile;
DOI:10.1021/jo00324a010