5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Base Information

Chemical Name:5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)
CAS No.:76991-45-2
Molecular Formula:C₃₇H₄₀Cl₄N₅O₁₃P
Molecular Weight:935.536
Hs Code.:

Synonyms:5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

There total 3 articles about 5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 59819-52-2
2,2,2-trichloroethyl 2-chlorophenyl phosphorochloridate

: 76991-44-1
5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine

: 76991-45-2
5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: With 1-methyl-1H-imidazole; In acetonitrile; at 0 ℃; for 0.75h;
DOI:10.1021/jo00324a010

Reference yield:

: 71874-01-6
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine

: 76991-45-2
5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 2-chloro-1-methylpyridinium iodide, 1,4-diazabicyclo<2.2.2>octane / acetonitrile; dioxane / 2 h

2: 86 percent / 1-methylimidazole / acetonitrile / 0.75 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1-methyl-1H-imidazole; 2-chloro-1-methyl-pyridinium iodide; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 123-76-2
levulinic acid

: 76991-45-2
5'-O-levulinyl-3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 2'-O-(2-chlorophenyl 2,2,2-trichloroethyl phosphate)

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 2-chloro-1-methylpyridinium iodide, 1,4-diazabicyclo<2.2.2>octane / acetonitrile; dioxane / 2 h

2: 86 percent / 1-methylimidazole / acetonitrile / 0.75 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1-methyl-1H-imidazole; 2-chloro-1-methyl-pyridinium iodide; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo00324a010