(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

Base Information

Chemical Name:(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester
CAS No.:317845-13-9
Molecular Formula:C₁₄H₁₅F₃N₂O₄
Molecular Weight:332.279
Hs Code.:

Synonyms:(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

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Technology Process of (1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

There total 2 articles about (1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 64-18-6
formic acid

: 317845-11-7
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

: 317845-13-9
(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1055/s-2000-8198

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 317845-13-9
(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / propan-2-ol / 20 °C

2: 76 percent / DEAD; PPh₃ / tetrahydrofuran / 15 h / 20 °C

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; isopropyl alcohol; 1: Condensation / 2: Esterification;
DOI:10.1055/s-2000-8198

Reference yield: 98.0%

: 317845-13-9
(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

: (1R)-N-[(1S)-1-Carbamoyl-2-phenylethyl]-4,4,4-trifluoro-2-hydroxybutyramide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 48h;
DOI:10.1055/s-2000-8198