(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

Base Information

Chemical Name:(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide
CAS No.:317845-11-7
Molecular Formula:C₁₃H₁₅F₃N₂O₃
Molecular Weight:304.269
Hs Code.:

Synonyms:(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

Suppliers and Price of (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

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Technology Process of (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

There total 1 articles about (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 5241-58-7
L-Phenylalanine amide

: 291772-62-8
(S)-5-(2,2,2-Trifluoro-ethyl)-2,2-bis-trifluoromethyl-[1,3]dioxolan-4-one

: 317845-11-7
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

Guidance literature:: In isopropyl alcohol; at 20 ℃;
DOI:10.1055/s-2000-8198

Reference yield: 76.0%

: 64-18-6
formic acid

: 317845-11-7
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

: 317845-13-9
(1R)-Formic acid 1-(1S)-1-carbamyl-2-phenylethylcarbamoyl-3,3,3-trifluoropropyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1055/s-2000-8198

Reference yield:

: 317845-11-7
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-4,4,4-trifluoro-2-hydroxy-butyramide

: (1R)-N-[(1S)-1-Carbamoyl-2-phenylethyl]-4,4,4-trifluoro-2-hydroxybutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / DEAD; PPh₃ / tetrahydrofuran / 15 h / 20 °C

2: 98 percent / H₂; HCl / Pd/C / methanol / 48 h / 20 °C

With hydrogenchloride; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Esterification / 2: Catalytic hydrogenation;
DOI:10.1055/s-2000-8198