Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

Base Information

Chemical Name:Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester
CAS No.:205238-42-2
Molecular Formula:C₂₆H₂₅NO₇S₂
Molecular Weight:527.619
Hs Code.:

Synonyms:Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

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Chemical Property of Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

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Technology Process of Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

There total 4 articles about Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98-59-9
p-toluenesulfonyl chloride

: 205238-30-8
Acetic acid (S)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-hydroxy-propyl ester

: 205238-42-2
Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; Ambient temperature;
DOI:10.3987/com-97-s39

Reference yield:

: 80360-14-1
3-iodo-1-phenylsulfonyl-1H-indole

: 205238-42-2
Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Pd(OAc)2, Ph₃P, n-Bu₄NCl, KOAc / dimethylformamide / 80 °C

2: 53 percent / O₃, sodium borohydride / ethanol / -78 - 0 °C

3: 82 percent / lipase AK / benzene / Ambient temperature

4: 90 percent / Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

With dmap; palladium diacetate; sodium tetrahydroborate; lipase AK; tetrabutyl-ammonium chloride; potassium acetate; ozone; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.3987/com-97-s39

Reference yield:

: 205238-29-5
2-(1-Benzenesulfonyl-1H-indol-3-yl)-propane-1,3-diol

: 205238-42-2
Acetic acid (R)-2-(1-benzenesulfonyl-1H-indol-3-yl)-3-(toluene-4-sulfonyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / lipase AK / benzene / Ambient temperature

2: 90 percent / Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

With dmap; lipase AK; triethylamine; In dichloromethane; benzene;
DOI:10.3987/com-97-s39