(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:1076206-88-6
Molecular Formula:C₁₇H₂₂F₃N₃O₃
Molecular Weight:373.375
Hs Code.:

Synonyms:(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

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Chemical Property of (2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

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Technology Process of (2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

There total 4 articles about (2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076206-86-4
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

: 1076206-88-6
(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: (2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333 - 0.166667h;

With ammonium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 796096-64-5
(S)-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1076206-88-6
(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 - 24 h / 20 °C

2.1: sodium hydroxide; ethanol; water / 20 °C

2.2: pH 5 - 6

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 - 0.17 h / 20 °C

3.2: 16 h / 20 °C

With sodium hydroxide; ethanol; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1076206-82-0
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester

: 1076206-88-6
(2S)-2-(aminocarbonyl)-4-[(2,3,5-trifluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol; water / 20 °C

1.2: pH 5 - 6

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 - 0.17 h / 20 °C

2.2: 16 h / 20 °C

With sodium hydroxide; ethanol; water; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;