(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

Base Information

Chemical Name:(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester
CAS No.:1076206-86-4
Molecular Formula:C₁₇H₂₁F₃N₂O₄
Molecular Weight:374.36
Hs Code.:

Synonyms:(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

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Chemical Property of (2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

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Technology Process of (2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

There total 3 articles about (2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076206-82-0
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester

: 1076206-86-4
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

Guidance literature:: (2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester; With sodium hydroxide; ethanol; water; at 20 ℃;

With water; citric acid; pH=5 - 6;

Reference yield:

: 796096-64-5
(S)-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1076206-86-4
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 - 24 h / 20 °C

2.1: sodium hydroxide; ethanol; water / 20 °C

2.2: pH 5 - 6

With sodium hydroxide; ethanol; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 226717-83-5
1-(bromomethyl)-2,3,5-trifluorobenzene

: 1076206-86-4
(2S)-4-[(2,3,5-trifluorophenyl)methyl]-1,2-piperazinedicarboxylic acid 1-(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 - 24 h / 20 °C

2.1: sodium hydroxide; ethanol; water / 20 °C

2.2: pH 5 - 6

With sodium hydroxide; ethanol; water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;