N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

Base Information

Chemical Name:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide
CAS No.:1292849-80-9
Molecular Formula:C₂₆H₃₃Cl₂N₃O₃
Molecular Weight:506.472
Hs Code.:

Synonyms:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

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Chemical Property of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

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Technology Process of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

There total 6 articles about N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292849-65-0
methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

: 1292849-80-9
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol; water / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 1292849-66-1
4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 1292849-80-9
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-80-9
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

3: potassium carbonate / methanol; water / 12 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065