N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

Base Information

Chemical Name:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide
CAS No.:1292849-81-0
Molecular Formula:C₂₇H₃₅Cl₂N₃O₅S
Molecular Weight:584.564
Hs Code.:

Synonyms:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

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Chemical Property of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

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Technology Process of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

There total 8 articles about N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1292849-80-9
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-oxo-4-piperazin-1-ylbutanamide

: 124-63-0
methanesulfonyl chloride

: 1292849-81-0
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 1292849-79-6
benzyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}-piperazine-1-carboxylate

: 1292849-81-0
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

2: triethylamine / dichloromethane / 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 1292849-66-1
4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 1292849-81-0
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N-(2,2-dimethylpropyl)-4-[4-(methylsulfonyl)-piperazin-1-yl]-4-oxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.01.065