ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate

Base Information

• Chemical Name: ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate
• CAS No.: 1315342-48-3
• Molecular Formula: C₂₂H₂₃F₂NO₂
• Molecular Weight: 371.427
• Mol file: 1315342-48-3.mol

Synonyms:ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate

Chemical Property of ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate

There total 2 articles about ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-N-(diphenylmethyleneamino)hex-5-enoate (912651-56-0) + Chlorodifluoromethane (75-45-6) → ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate (1315342-48-3)

Guidance literature:

ethyl 2-N-(diphenylmethyleneamino)hex-5-enoate; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

Chlorodifluoromethane; In tetrahydrofuran; at -78 - 20 ℃; for 0.916667h; Inert atmosphere;

DOI:10.1021/jm200443b

Reference yield:

ethyl N-diphenylmethylene glycine (69555-14-2) → ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate (1315342-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.92 h / -78 - 20 °C / Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1021/jm200443b

Reference yield: 45.0%

ethyl 2-N-(diphenylmethyleneamino)-2-(difluoromethyl)-hex-5-enoate (1315342-48-3) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → ethyl 2-N-(diphenylmethyleneamino)-2-difluoromethyl-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)hexanoate (1315342-50-7)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; bis-diphenylphosphinomethane; In dichloromethane; at 25 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm200443b

upstream raw materials:

ethyl 2-N-(diphenylmethyleneamino)hex-5-enoate

Chlorodifluoromethane

ethyl N-diphenylmethylene glycine

Downstream raw materials:

ethyl 2-N-(diphenylmethyleneamino)-2-difluoromethyl-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)hexanoate