[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

Base Information

Chemical Name:[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester
CAS No.:126110-97-2
Molecular Formula:C₃₆H₃₆N₂O₈
Molecular Weight:624.69
Hs Code.:

Synonyms:[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

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Chemical Property of [Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

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Technology Process of [Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

There total 5 articles about [Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126132-93-2
benzo[d][1,3]dioxol-5-ylglycine methyl ester

: 126110-97-2
[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

2: 1 N LiOH / dioxane / 1 h / Ambient temperature

3: ethyl acetate / 48 h / Ambient temperature

With pyridine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 126110-97-2
[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / triethylamine / tetrahydrofuran / 2 h / 0 °C

2: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C

3: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

4: 1 N LiOH / dioxane / 1 h / Ambient temperature

5: ethyl acetate / 48 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028

Reference yield:

: 126111-17-9
(S)-2-(acetyloxy)-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid

: 126110-97-2
[Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C

2: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

3: 1 N LiOH / dioxane / 1 h / Ambient temperature

4: ethyl acetate / 48 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00167a028