(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

Base Information

Chemical Name:(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide
CAS No.:623571-24-4
Molecular Formula:C₂₃H₂₉N₃O₆S₂
Molecular Weight:507.632
Hs Code.:

Synonyms:(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

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Chemical Property of (-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

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Technology Process of (-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

There total 8 articles about (-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 623571-23-3
(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14-oxide

: 623571-24-4
(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

Guidance literature:: With ruthenium trichloride; sodium periodate; In dichloromethane; water; acetonitrile; for 1.5h;
DOI:10.1002/hlca.200390160

Reference yield:

: 78521-64-9
N-(4-aminobutyl)-4-methyl benzenesulfonamide

: 623571-24-4
(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 82.6 percent / CH₂Cl₂ / 0.42 h

2: Cs₂CO₃ / dimethylformamide / 7 h / 20 °C

3: 85 percent / aq. Na₂CO₃ / propan-2-ol / 36 h / 70 °C

4: 100 percent / 1H-imidazole; SOCl₂ / CH₂Cl₂ / 0.5 h / 5 °C

5: 99 percent / NaIO₄; RuCl₃ / CH₂Cl₂; acetonitrile; H₂O / 1.5 h

With 1H-imidazole; ruthenium trichloride; sodium periodate; thionyl chloride; sodium carbonate; caesium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1002/hlca.200390160

Reference yield:

: 186179-24-8
1,1-dimethylethyl {4-{[(4-methylphenyl)sulfonyl]amino}butyl}carbamate

: 623571-24-4
(-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 87.9 percent / CF₃COOH / CH₂Cl₂ / 17 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 7 h / 20 °C

3: 85 percent / aq. Na₂CO₃ / propan-2-ol / 36 h / 70 °C

4: 100 percent / 1H-imidazole; SOCl₂ / CH₂Cl₂ / 0.5 h / 5 °C

5: 99 percent / NaIO₄; RuCl₃ / CH₂Cl₂; acetonitrile; H₂O / 1.5 h

With 1H-imidazole; ruthenium trichloride; sodium periodate; thionyl chloride; sodium carbonate; caesium carbonate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1002/hlca.200390160