78521-64-9

Upstream product

• 110-60-1 1,4-diaminobutane 
• 98-59-9 p-toluenesulfonyl chloride 
• 186179-24-8 1,1-dimethylethyl {4-{[(4-methylphenyl)sulfonyl]amino}butyl}carbamate 

Downstream Products

• 114942-29-9 N-<4-(tosylamino)butyl>formamide 
• 186179-24-8 1,1-dimethylethyl {4-{[(4-methylphenyl)sulfonyl]amino}butyl}carbamate 
• 15544-49-7 N-(N⁴-p-toluenesulfonyl)-4-aminobutylphthalimide 
• 422565-31-9 (S)-3-[(4-methylphenyl)sulfonylamino]-N-{4-[(4-methylphenyl)sulfonyl]aminobutyl}-3-phenylpropanamide 
• 623571-06-2 2,2,2-trifluoro-N-{4-{[(4-methylphenyl)sulfonyl]amino}butyl}acetamide 
• 623571-45-9 (+)-(2R,3R)-3-hydroxy-9-[(4-methylphenyl)sulfonyl]-2-phenyl-1,5,9-triazacyclotridecan-4-one 
• 623571-26-6 (-)-(2R,3S)-3-hydroxy-9-[(4-methylphenyl)sulfonyl]-2-phenyl-1,5,9-triazatridecan-4-one 
• 623571-23-3 (-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14-oxide 
• 623571-24-4 (-)-(12R,15R)-6-[(4-methylphenyl)sulfonyl]-15-phenyl-13-oxa-14-thia-1,6,10-triazabicyclo[10.2.1]pentadecan-11-one 14,14-dioxide 
• 623571-39-1 (+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide 
• 623571-21-1 (+)-(2S,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide 

Relevant academic research and scientific papers

Tertiary enamide-promoted diastereoselective domino: N-acyliminium ion trapping and nazarov cyclization

N-Acyliminium ions generated from enamidyl vinyl ketones provided cyclopentenoid-fused diazepines diastereoselectively using BF3·Et2O in one pot through a domino N-acyliminium ion trapping/Nazarov reaction, simultaneously generating three new stereogenic centers. The particular structural design of the cross-conjugated dienone dictates the torquoselectivity observed in this polarized Nazarov reaction. Various N-bridgehead polycyclic scaffolds of putative pharmacological interest were obtained. Cyclic voltammetry was used to support the preferred reaction sequence within this domino reaction.

Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles

Enamides equipped with N-acyliminium ion precursors were obtained through reduction of ynamides tethered to N-imides. Intramolecular TMSOTf-mediated trapping of N-acyliminium ions provided a variety of polyfunctionalized medium-sized diaza-heterocycles of putative pharmacological interest.

A novel synthesis of the macrocyclic spermidine alkaloid (+)-(S)-dihydroperiphylline

A novel, short, and highly stereoselective synthesis of the macrocyclic spermidine alkaloid (+)-(S)-dihydroperiphylline (15) is described. The key synthetic steps were the stereoselective addition of the chiral amine 1 to the cinnamate 2 and cyclization o

Investigations on New Strategies for the Facile Synthesis of Polyfunctionalized Phosphinates: Phosphinopeptide Analogues of Glutathionylspermidine

Three possible methods for the facile synthesis of functionalized phosphinates, including the core of complex phosphinopeptide analogues of glutathionylspermidine, were explored. Among these methods, the three-component condensation reaction involving ben

Synthesis of Polyamine-Carbodiimides. - Potential Activators for Chemical Ligations of Oligodeoxynucleotide 3'-Phosphates

Polyamine-Carbodiimides are new water-soluble activating agents designed to fit some requirements of chemical ligations of oligodeoxynucleotide 3'-phosphates.N-Alkyl-N'-(4,9,13-trimethyl-4,9,13-triazatetradecyl)carbodiimides 9 have been prepared from 4,9,