1-(2-Phenoxyethyl)-4-phenylpiperazine

Base Information

Chemical Name:1-(2-Phenoxyethyl)-4-phenylpiperazine
CAS No.:1037-20-3
Molecular Formula:C18H22 N2 O
Molecular Weight:282.385
Hs Code.:2933599090
NSC Number:34065
UNII:9MFB5HG74Y
DSSTox Substance ID:DTXSID60146014
Nikkaji Number:J322.424D
Wikidata:Q83010734
ChEMBL ID:CHEMBL52752
Mol file:1037-20-3.mol

Synonyms:1-(2-Phenoxyethyl)-4-phenylpiperazine;1037-20-3;Piperazine, 1-(2-phenoxyethyl)-4-phenyl-;1-(2-PHENOXYETHYL)-4-PHENYL-PIPERAZINE;NSC-34065;NSC 34065;BRN 0266105;NSC34065;ChemDiv2_002426;9MFB5HG74Y;Oprea1_265574;Oprea1_863518;4-23-00-00097 (Beilstein Handbook Reference);CHEMBL52752;DTXSID60146014;HMS1375O06;STK697110;AKOS003826848

Suppliers and Price of 1-(2-Phenoxyethyl)-4-phenylpiperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(2-PHENOXYETHYL)-4-PHENYL-PIPERAZINE 95.00%
5MG
$ 503.03

Total 9 raw suppliers

Chemical Property of 1-(2-Phenoxyethyl)-4-phenylpiperazine

Chemical Property:

Vapor Pressure:1.06E-07mmHg at 25°C
Boiling Point:433°Cat760mmHg
Flash Point:128°C
PSA：15.71000
Density:1.091g/cm³
LogP:2.89050
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:282.173213330
Heavy Atom Count:21
Complexity:277

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-PHENOXYETHYL)-4-PHENYL-PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CCOC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(2-Phenoxyethyl)-4-phenylpiperazine

There total 11 articles about 1-(2-Phenoxyethyl)-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 92-54-6
4-phenyl-1-piperazine

: 141482-06-6
1-methanesulfonyloxy-2-(phenoxy)ethane

: 1037-20-3
1-(2-phenoxyethyl)-4-phenylpiperazine

Guidance literature:: With lithium carbonate; In acetonitrile; for 24h; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.032

Reference yield: 79.0%

: 1-phenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate

: 108-95-2,27073-41-2
phenol

: 1037-20-3
1-(2-phenoxyethyl)-4-phenylpiperazine

Guidance literature:: phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.666667h;

1-phenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 10h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.8b02676

Reference yield:

: 66003-76-7
Diphenyliodonium triflate

: 1037-20-3
1-(2-phenoxyethyl)-4-phenylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 12 h / 60 °C / Sealed tube

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 5 °C

2.2: 10 h / 60 °C / Inert atmosphere; Sealed tube

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/acs.orglett.8b02676