1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 467443-30-7
• Molecular Formula: C₂₄H₂₃ClN₂O₅
• Molecular Weight: 454.91
• Mol file: 467443-30-7.mol

Synonyms:1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Chemical Property of 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

There total 8 articles about 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

oxalyl dichloride (79-37-8) + 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester (467443-22-7) → 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester (467443-30-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) → 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester (467443-30-7)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride

2: sodium azide / toluene / 1 h / Heating

3: 72 percent / CHCl₃ / 3 h / 20 °C

4: 89 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; In tetrahydrofuran; chloroform; toluene;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

4-chlorobenzyl bromide (622-95-7) → 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester (467443-30-7)

Guidance literature:

Multi-step reaction with 6 steps

1: AcOH; H₂SO₄

2: thionyl chloride

3: sodium azide / toluene / 1 h / Heating

4: 72 percent / CHCl₃ / 3 h / 20 °C

5: 89 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; sulfuric acid; acetic acid; In tetrahydrofuran; chloroform; toluene;

DOI:10.3797/scipharm.aut-01-204

upstream raw materials:

oxalyl dichloride

1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester

4-chlorophenylacetic Acid

1-aminocyclohexanecarboxylic acid benzyl ester