3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

Base Information

Chemical Name:3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide
CAS No.:1070292-60-2
Molecular Formula:C₂₇H₂₃BrN₂O₂
Molecular Weight:487.396
Hs Code.:

Synonyms:3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

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Chemical Property of 3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

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Technology Process of 3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

There total 4 articles about 3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-61-3
3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

: 765-30-0
Cyclopropylamine

: 1070292-60-2
3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: 3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester; Cyclopropylamine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070292-60-2
3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 82827-09-6
6-bromo-2H-isoquinoline-1-one

: 1070292-60-2
3-[2-(4-Bromo-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;