3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Base Information

Chemical Name:3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester
CAS No.:1070292-61-3
Molecular Formula:C₂₅H₂₀BrNO₃
Molecular Weight:462.343
Hs Code.:

Synonyms:3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

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Chemical Property of 3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

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Technology Process of 3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

There total 3 articles about 3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1070292-61-3
3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: 4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-bromomethyl-4-bromobenzene; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070292-61-3
3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 82827-09-6
6-bromo-2H-isoquinoline-1-one

: 1070292-61-3
3-[2-(4-bromobenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;