CH₃(CH₂)2CH=CHCONHPh

Base Information

• Chemical Name: CH₃(CH₂)2CH=CHCONHPh
• CAS No.: 1483-36-9
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 1483-36-9.mol

Synonyms:CH₃(CH₂)2CH=CHCONHPh

Chemical Property of CH₃(CH₂)2CH=CHCONHPh

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of CH₃(CH₂)2CH=CHCONHPh

There total 10 articles about CH₃(CH₂)2CH=CHCONHPh which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

carbon monoxide (201230-82-2) + C13H27Al + Phenyl azide (622-37-7) → CH3(CH2)2CH=CHCONHPh (1483-36-9)

Guidance literature:

With palladium diacetate; XPhos; In tetrahydrofuran; hexane; at 80 ℃; for 16h; under 7500.75 Torr; Inert atmosphere; Sealed tube; Autoclave;

DOI:10.1016/j.jcat.2020.01.017

Reference yield: 79.0%

C13H27Al + phenyl isocyanate (103-71-9) → (E)-N-phenylhex-2-enamide (1483-36-9)

Guidance literature:

In tetrahydrofuran; at 0 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0037-1610753

Reference yield:

(E)-2-hexenoyl chloride (97943-16-3) + aniline (62-53-3) → N-phenylhex-3-enamide (859189-41-6) + CH3(CH2)2CH=CHCONHPh (1483-36-9)

Guidance literature:

(E)-2-hexenoyl chloride; With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

aniline; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2011.05.096

upstream raw materials:

aniline

(E)-2-hexenoyl chloride

(E)-2-Hexenoic acid

2-hexenoic acid

Downstream raw materials:

3-methoxy-N-phenylhexanamide

3-piperidino-hexanoic acid anilide

Refernces

• 1、 Chen, Bo,Wu, Xiao-Feng. "Palladium-catalyzed carbonylative synthesis of α,β-unsaturated amides from aryl azides and alkenylaluminum reagent". . p. 160 - 163. Retrieved 2020/02/11.
• 2、 Wang, Zi-Xuan,Bai, Xiao-Yan,Yao, Han-Chao,Li, Bi-Jie. "Synthesis of Amides with Remote Stereocenters by Catalytic Asymmetric γ-Alkynylation of α,β-Unsaturated Amides". supporting information. p. 14872 - 14875. Retrieved 2016/11/28.