ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate
• CAS No.: 109406-75-9
• Molecular Formula: C₁₅H₁₇N₃O₂S
• Molecular Weight: 303.385

Synonyms:ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate

Chemical Property of ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate

Chemical Property:

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Technology Process of ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate

There total 5 articles about ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 2-chloro-3-oxo-butyrate (609-15-4) + [(1-aza-2-phenylprop-1-enyl)amino]aminomethane-1-thione (132121-93-8) → ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate (109406-75-9)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.08.054

Reference yield:

acetophenone (98-86-2) → ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate (109406-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / Reflux

2: ethanol / Reflux

With acetic acid; In ethanol;

DOI:10.1016/j.ejmech.2013.08.054

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 4-methyl-2-[(E)-2-(1-phenylethylidene)hydrazin-1-yl]-1,3-thiazole-5-carboxylate (109406-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: ethanol; acetic acid

With ethanol; acetic acid;

upstream raw materials:

ethyl 2-hydrazinyl-4-methylthiazole-5-carboxylate

acetophenone

2-(N'-acetyl-hydrazino)-4-methyl-thiazole-5-carboxylic acid ethyl ester

ethyl 2-chloro-3-oxo-butyrate

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