N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

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Chemical Name:N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide
CAS No.:1383446-20-5
Molecular Formula:C₄₀H₃₆FN₉O
Molecular Weight:677.784
Hs Code.:

Synonyms:N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

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Chemical Property of N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

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Technology Process of N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

There total 4 articles about N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36404-90-7
2-fluoropyridine-3-carboxaldehyde

: 1383446-20-5
N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 1 h / 80 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.67 h / 44 °C

3: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice

4: potassium acetate / bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1.5 h / 100 °C / Inert atmosphere

5: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 2-methyl-THF / 2 h / 80 °C / Inert atmosphere; Sealed vial

With potassium phosphate; N-Bromosuccinimide; potassium acetate; sodium hydride; hydrazine hydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(pinacol)diborane; XPhos; In 2-methyl-THF; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 68618-36-0
3-Bromo-1H-pyrazolo<3,4-b>pyridine

: 1383446-20-5
N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice

2: potassium acetate / bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1.5 h / 100 °C / Inert atmosphere

3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 2-methyl-THF / 2 h / 80 °C / Inert atmosphere; Sealed vial

With potassium phosphate; potassium acetate; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(pinacol)diborane; XPhos; In 2-methyl-THF; N,N-dimethyl-formamide;

Reference yield:

: 271-73-8
1H-Pyrazolo[3,4-b]pyridine

: 1383446-20-5
N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.67 h / 44 °C

2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice

3: potassium acetate / bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1.5 h / 100 °C / Inert atmosphere

4: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 2-methyl-THF / 2 h / 80 °C / Inert atmosphere; Sealed vial

With potassium phosphate; N-Bromosuccinimide; potassium acetate; sodium hydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(pinacol)diborane; XPhos; In 2-methyl-THF; N,N-dimethyl-formamide;