2-Fluoro-3-formylpyridine

Base Information

• Chemical Name: 2-Fluoro-3-formylpyridine
• CAS No.: 36404-90-7
• Molecular Formula: C6H4FNO
• Molecular Weight: 125.102
• Hs Code.: 2933399990
• European Community (EC) Number: 628-312-8
• DSSTox Substance ID: DTXSID00465675
• Nikkaji Number: J1.982.695C
• Wikidata: Q72476762
• Mol file: 36404-90-7.mol

Synonyms:2-Fluoro-3-formylpyridine;36404-90-7;2-fluoropyridine-3-carbaldehyde;2-fluoronicotinaldehyde;2-Fluoropyridine-3-carboxaldehyde;2-Fluoro-3-pyridinecarboxaldehyde;2-Fluoro-3-pyridine carboxaldehyde;3-PYRIDINECARBOXALDEHYDE, 2-FLUORO-;MFCD03095270;2-Fluoro-pyridine-3-carbaldehyde;3-pyridinecarboxaldehyde,2-fluoro-;fluoronicotinealdehyde;SCHEMBL172054;2-fluoropyridin-3-carboxaldehyde;2-fluoro-3-pyridine-carbaldehyde;DTXSID00465675;OFBVGDCXXGXDKU-UHFFFAOYSA-N;DL-NORMETANEPHRINEHYDROCHLORIDE;AKOS005063861;AB13640;CS-W019721;PS-9206;2-Fluoro-3-pyridinecarboxaldehyde, 97%;AC-24507;SY014361;A6297;AM20070136;FT-0650042;EN300-111984;J-509525

Chemical Property of 2-Fluoro-3-formylpyridine

Chemical Property:

• Refractive Index: n20/D 1.520
• Boiling Point: 220.84 °C at 760 mmHg
• PKA: -2.23±0.10(Predicted)
• Flash Point: 87.361 °C
• Density: 1.27 g/cm³
• Storage Temp.: Room temperature.
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 125.027691913
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoropyridine-3-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)F)C=O
• Uses: Attachment of isoxazolinones by displacement of fluoride provide naphthyridines on hydrogenolysis and cyclization.

Technology Process of 2-Fluoro-3-formylpyridine

There total 9 articles about 2-Fluoro-3-formylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-Formylpiperidine (2591-86-8) + 2-fluoropyridine (372-48-5) → 2-fluoropyridine-3-carboxaldehyde (36404-90-7)

Guidance literature:

2-fluoropyridine; With trimethylsilylmethyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -50 ℃; for 3h;

N-Formylpiperidine; In tetrahydrofuran; hexane; at -50 - 20 ℃;

Reference yield: 83.0%

→ 2-fluoropyridine-3-carboxaldehyde (36404-90-7)

Guidance literature:

Reference yield: 67.0%

2-fluoro-3-(hydroxymethyl)pyridine (131747-55-2) → 2-fluoropyridine-3-carboxaldehyde (36404-90-7)

Guidance literature:

With phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.38.2446

upstream raw materials:

N-Formylpiperidine

2-fluoropyridine

2-fluoro-3-(hydroxymethyl)pyridine

5-bromo-2-fluoropyridine

Downstream raw materials:

2-Fluoro-2',6'-dimethyl-1',4'-dihydro-[3,4']bipyridinyl-3',5'-dicarboxylic acid 5'-[2-(benzyl-methyl-amino)-ethyl] ester 3'-methyl ester

2-(benzenesulfonyl)pyridine-3-carboxaldehyde

2-fluoro-3-{2-fluoro-2-[4-(trifluoromethyl)phenyl]vinyl}pyridine

2-fluoro-3-(hydroxymethyl)pyridine