N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Base Information

Chemical Name:N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide
CAS No.:1282612-99-0
Molecular Formula:C₂₄H₂₆FN₃O₂S
Molecular Weight:439.554
Hs Code.:

Synonyms:N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Suppliers and Price of N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

There total 6 articles about N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1220870-13-2
5-[4-(allyloxy)-3,5-dimethylphenyl]-N-butyl-1,3,4-thiadiazol-2-amine

: 393-52-2
2-Fluorobenzoyl chloride

: 1282612-99-0
N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Guidance literature:: 5-[4-(allyloxy)-3,5-dimethylphenyl]-N-butyl-1,3,4-thiadiazol-2-amine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-Fluorobenzoyl chloride; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 1282612-99-0
N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 5 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 20 - 110 °C / Sealed

2.2: pH 1

3.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1.5 h / 20 °C

With water; sodium hydride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 592-82-5
butyl isothiocyanate

: 1282612-99-0
N-(5-(4-(Allyloxy)-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl)-N-butyl-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol / 10 - 15 °C

2.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 1.5 h / 20 °C

With sodium hydride; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol;