N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

Base Information

Chemical Name:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt
CAS No.:1351522-29-6
Molecular Formula:CH₄O₃S*C₂₉H₃₈N₆O₄
Molecular Weight:630.765
Hs Code.:

Synonyms:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

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Chemical Property of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

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Technology Process of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

There total 5 articles about N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1351522-28-5
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

: 1351522-29-6
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

Guidance literature:: In ethanol; at 60 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml300214g

Reference yield: 98.0%

: 1351522-29-6
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

Guidance literature:

Reference yield:

: 327056-62-2
5-fluoropicolinonitrile

: 1351522-29-6
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide methanesulfonate salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide; water / ethanol / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 3 h / 20 °C

4.1: ethanol / 1 h / 60 °C / Inert atmosphere

With water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml300214g