N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

Base Information

Chemical Name:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide
CAS No.:1351522-28-5
Molecular Formula:C₂₉H₃₈N₆O₄
Molecular Weight:534.659
Hs Code.:

Synonyms:N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

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Chemical Property of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

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Technology Process of N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

There total 5 articles about N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1351522-28-5
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

Guidance literature:

Reference yield:

: 852668-37-2
1-(4-aminophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea

: 1351503-96-2
5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinic acid

: 1351522-28-5
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

Guidance literature:: 5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

1-(4-aminophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/ml300214g

Reference yield:

: 327056-62-2
5-fluoropicolinonitrile

: 1351522-28-5
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide; water / ethanol / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 3 h / 20 °C

With water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml300214g