8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

Base Information

Chemical Name:8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine
CAS No.:116437-99-1
Molecular Formula:C₂₀H₂₂N₂O₂
Molecular Weight:322.407
Hs Code.:

Synonyms:8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

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Chemical Property of 8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

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Technology Process of 8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

There total 1 articles about 8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 88609-66-9
1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

: 116437-99-1
8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; for 24h; under 760 Torr;
DOI:10.1021/jo00257a031

Reference yield: 40.0%

: 546-67-8
lead(IV) tetraacetate

: 116437-99-1
8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

: 116438-00-7
8-(acetylimino)-1-benzyl-6,9-dimethyl-2,5,7-trioxo-1,2,3,4,5,6,7,8-1-benzazocine

Guidance literature:: In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jo00257a031

Reference yield:

: 116437-99-1
8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

: 116438-11-0
6,9-dimethyl-7,10-dioxo-5,5-(ethylenedioxy)-8-methoxy-1-(p-tolylsulfonyl)-1,2,3,4,5,6,7,10-octahydro-1-benzazocine

Guidance literature:: Multi-step reaction with 11 steps

1: 40 percent / CH₂Cl₂ / 0.25 h / 0 °C

2: 95 percent / 60percent aq. perchloric acid / tetrahydrofuran; CH₂Cl₂ / 0.17 h / 0 °C

3: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.5 h

4: 92 percent / K₂CO₃, 18-crown-6 / acetone / 2.5 h / Heating

5: chlorotrimethylsilane / methanol; CH₂Cl₂ / 4 h / Ambient temperature

6: H₂ / 10percent Pd/C / tetrahydrofuran / 14 h

7: K₂CO₃, 18-crown-6 / CHCl₃ / 45 h / Ambient temperature

8: LiAlH₄ / tetrahydrofuran / 1 h / Ambient temperature

9: H₂ / 20percent Pd(OH)2/C / methanol / 5 h / Ambient temperature

10: pyridine / CH₂Cl₂ / 40 h / Ambient temperature

11: 94 percent / bis(salicylidene)ethylenediiminocobalt(II), O₂ / dimethylformamide / 3 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; chloro-trimethyl-silane; perchloric acid; salcomine; 18-crown-6 ether; hydrogen; oxygen; potassium carbonate; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00257a031