1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

Base Information

Chemical Name:1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone
CAS No.:1027240-27-2
Molecular Formula:C₂₂H₁₆F₃NO₃
Molecular Weight:399.369
Hs Code.:

Synonyms:1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

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Chemical Property of 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

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Technology Process of 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

There total 12 articles about 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027089-90-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

: 1027240-27-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

Guidance literature:: With jones reagent; In acetone; at 10 ℃; for 0.5h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1027240-27-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

Guidance literature:: Multi-step reaction with 10 steps

1: HCl / ethyl acetate

2: POCl₃ / CHCl₃

3: CHCl₃

4: NaOMe / ethanol

5: NaBH₄ / methanol; tetrahydrofuran

6: Et₃SiH; TFA / CH₂Cl₂

7: dimethylformamide

8: Al-Ni; 70percent aq. formic acid

9: tetrahydrofuran / 0.83 h / 0 - 20 °C

10: Jones reagent / acetone / 0.5 h / 10 °C

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; jones reagent; sodium methylate; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: Condensation / 2: deoxygenation / 3: Bromination / 4: Condensation / 5: Reduction / 6: Reduction / 7: cyanidation / 8: Reduction / 9: Grignard reaction / 10: Oxidation;
DOI:10.1021/jm990476x

Reference yield:

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 1027240-27-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: NaOMe / ethanol

2: NaBH₄ / methanol; tetrahydrofuran

3: Et₃SiH; TFA / CH₂Cl₂

4: dimethylformamide

5: Al-Ni; 70percent aq. formic acid

6: tetrahydrofuran / 0.83 h / 0 - 20 °C

7: Jones reagent / acetone / 0.5 h / 10 °C

With triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; jones reagent; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1: Condensation / 2: Reduction / 3: Reduction / 4: cyanidation / 5: Reduction / 6: Grignard reaction / 7: Oxidation;
DOI:10.1021/jm990476x