1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

Base Information

Chemical Name:1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol
CAS No.:1027089-90-2
Molecular Formula:C₂₂H₁₈F₃NO₃
Molecular Weight:401.385
Hs Code.:

Synonyms:1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

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Chemical Property of 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

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Technology Process of 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

There total 11 articles about 1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1027089-90-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

Guidance literature:: Multi-step reaction with 9 steps

1: HCl / ethyl acetate

2: POCl₃ / CHCl₃

3: CHCl₃

4: NaOMe / ethanol

5: NaBH₄ / methanol; tetrahydrofuran

6: Et₃SiH; TFA / CH₂Cl₂

7: dimethylformamide

8: Al-Ni; 70percent aq. formic acid

9: tetrahydrofuran / 0.83 h / 0 - 20 °C

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; sodium methylate; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; 1: Condensation / 2: deoxygenation / 3: Bromination / 4: Condensation / 5: Reduction / 6: Reduction / 7: cyanidation / 8: Reduction / 9: Grignard reaction;
DOI:10.1021/jm990476x

Reference yield:

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 1027089-90-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: NaOMe / ethanol

2: NaBH₄ / methanol; tetrahydrofuran

3: Et₃SiH; TFA / CH₂Cl₂

4: dimethylformamide

5: Al-Ni; 70percent aq. formic acid

6: tetrahydrofuran / 0.83 h / 0 - 20 °C

With triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction / 3: Reduction / 4: cyanidation / 5: Reduction / 6: Grignard reaction;
DOI:10.1021/jm990476x

Reference yield:

: 1026449-32-0
1-{5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}ethanone

: 1027089-90-2
1-{2-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-benzofuran-5-yl}-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: CHCl₃

2: NaOMe / ethanol

3: NaBH₄ / methanol; tetrahydrofuran

4: Et₃SiH; TFA / CH₂Cl₂

5: dimethylformamide

6: Al-Ni; 70percent aq. formic acid

7: tetrahydrofuran / 0.83 h / 0 - 20 °C

With triethylsilane; sodium tetrahydroborate; nickel-aluminum alloy; sodium methylate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 1: Bromination / 2: Condensation / 3: Reduction / 4: Reduction / 5: cyanidation / 6: Reduction / 7: Grignard reaction;
DOI:10.1021/jm990476x