1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

Base Information

Chemical Name:1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate
CAS No.:1254101-36-4
Molecular Formula:C₃₅H₄₇N₃O₄Si
Molecular Weight:601.861
Hs Code.:

Synonyms:1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

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Chemical Property of 1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

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Technology Process of 1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

There total 7 articles about 1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254102-02-7
3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate hydrochloride

: 131230-76-7
4-[(tert-butyldimethylsilyloxy)methyl]aniline

: 1254101-36-4
1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 163596-75-6
4-bromo-3-nitrobenzaldehyde

: 1254101-36-4
1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Inert atmosphere; Cooling with ice

1.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 16 h / 20 °C

4.1: acetonitrile / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 16 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 70 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1254102-15-2
tert-butyl trans-3-(3-nitro-4-phenylphenyl)acrylate

: 1254101-36-4
1-methylpiperidin-4-yl N-{5-[2-({4-[(tert-butyldimethylsilanoyloxy)methyl]phenyl}carbamoyl)ethyl]-2-phenylphenyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 16 h / 20 °C

2.1: acetonitrile / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 16 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 70 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;