4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

Base Information

Chemical Name:4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide
CAS No.:1254099-87-0
Molecular Formula:C₃₀H₃₆N₃O₄*I
Molecular Weight:629.538
Hs Code.:

Synonyms:4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

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Chemical Property of 4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

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Technology Process of 4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

There total 10 articles about 4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254100-76-9
1-methylpiperidin-4-yl N-[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamate

: 74-88-4
methyl iodide

: 1254099-87-0
4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

Guidance literature:: In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 163596-75-6
4-bromo-3-nitrobenzaldehyde

: 1254099-87-0
4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Inert atmosphere; Cooling with ice

1.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 16 h / 20 °C

4.1: acetonitrile / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 16 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 70 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 1.5 h / 70 °C

8.1: acetonitrile / 1 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; caesium carbonate; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1254102-15-2
tert-butyl trans-3-(3-nitro-4-phenylphenyl)acrylate

: 1254099-87-0
4-({[5-(2-{[4-(hydroxymethyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-iumiodide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 16 h / 20 °C

2.1: acetonitrile / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 16 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 70 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 1.5 h / 70 °C

6.1: acetonitrile / 1 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;