syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

Base Information

Chemical Name:syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione
CAS No.:1178976-77-6
Molecular Formula:C₂₃H₂₁ClFN₅O₄
Molecular Weight:485.902
Hs Code.:

Synonyms:syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

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Chemical Property of syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

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Technology Process of syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

There total 6 articles about syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: potassium cyanide

: 1046137-42-1
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(4-oxo-cyclohexyloxy)-7-methoxy-quinazoline

: 506-87-6,6721-33-1,10361-29-2
ammonium carbonate

: 1178976-77-6
syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

Guidance literature:: In ethanol; water; for 4h; Reflux;

Reference yield:

: 808793-56-8
3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

: 1178976-77-6
syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 80 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

3.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

3.2: 20 - 40 °C / Inert atmosphere

3.3: 20 °C

4.1: ethanol; water / 4 h / Reflux

With hydrogen; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 141120-33-4
8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane

: 1178976-77-6
syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 80 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

3.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

3.2: 20 - 40 °C / Inert atmosphere

3.3: 20 °C

4.1: ethanol; water / 4 h / Reflux

With hydrogen; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;