cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

Base Information

Chemical Name:cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid
CAS No.:1178976-89-0
Molecular Formula:C₂₂H₂₂ClFN₄O₄
Molecular Weight:460.892
Hs Code.:

Synonyms:cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

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Chemical Property of cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

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Technology Process of cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

There total 7 articles about cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178976-77-6
syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione

: 1178976-89-0
cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

Guidance literature:: syn/anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione; With water; sodium hydroxide; at 135 ℃; for 25h;

With hydrogenchloride; In water; at 20 ℃;

Reference yield:

: 1046452-35-0
3-benzyl-3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline

: 1178976-89-0
cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

2.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

2.2: 20 - 40 °C / Inert atmosphere

2.3: 20 °C

3.1: ethanol; water / 4 h / Reflux

4.1: sodium hydroxide; water / 25 h / 135 °C

4.2: 20 °C

With water; hydrogen; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In ethanol; water; acetonitrile;

Reference yield:

: 808793-56-8
3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

: 1178976-89-0
cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 80 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

3.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

3.2: 20 - 40 °C / Inert atmosphere

3.3: 20 °C

4.1: ethanol; water / 4 h / Reflux

5.1: sodium hydroxide; water / 25 h / 135 °C

5.2: 20 °C

With water; hydrogen; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;