ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

Base Information

Chemical Name:ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate
CAS No.:1204976-90-8
Molecular Formula:C₂₅H₂₈FN₅O₂
Molecular Weight:449.528
Hs Code.:

Synonyms:ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

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Chemical Property of ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

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Technology Process of ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

There total 3 articles about ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 132521-78-9
1-(5-ethoxycarbonyl-pyridin-2-yl)piperazine

: 1057682-70-8
3-chloro-6-(4-fluorobenzyl)-4,5-dimethylpyridazine

: 1204976-90-8
ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 210 ℃; for 1h; Microwave irradiation;
DOI:10.1002/cmdc.201300217

Reference yield:

: 34584-69-5
3,6-dichloro-4,5-dimethylpyridazine

: 1204976-90-8
ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 60 °C

2: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 210 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1: |Negishi Coupling;
DOI:10.1002/cmdc.201300217

Reference yield:

: 223761-28-2
(4-fluorobenzyl)zinc(II) bromide

: 1204976-90-8
ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 60 °C

2: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 210 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1: |Negishi Coupling;
DOI:10.1002/cmdc.201300217