(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

Base Information

Chemical Name:(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate
CAS No.:1448778-18-4
Molecular Formula:C₃₇H₃₅N₃O₉S
Molecular Weight:697.766
Hs Code.:

Synonyms:(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

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Chemical Property of (2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

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Technology Process of (2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

There total 3 articles about (2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1448777-99-8
2-((E)-2-nitrovinyl)-N-tosylbenzenamine

: 1318151-43-7
tert-butyl (E)-3-(2-(benzyloxy)-2-oxoethylidene)-2-oxoindoline-1-carboxylate

: 1448778-18-4
(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

Guidance literature:: With C₃₄H₃₁F₆N₃O₃; In dichloromethane; at 0 ℃; for 1h; stereoselective reaction;
DOI:10.1021/ol401595g

Reference yield:

: 328029-93-2
C₁₅H₁₆N₂O₅S

: 1448778-18-4
(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; pyridine / dichloromethane / 3 h / 0 - 20 °C

2: C₃₄H₃₁F₆N₃O₃ / dichloromethane / 1 h / 0 °C

With pyridine; thionyl chloride; C₃₄H₃₁F₆N₃O₃; In dichloromethane;
DOI:10.1021/ol401595g

Reference yield:

: 6590-65-4
N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

: 1448778-18-4
(2'R,3S,4'S)-2'-benzyl 1-tert-butyl 4'-(nitromethyl)-2-oxo-1'-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-1,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 3 h / 0 °C

2: thionyl chloride; pyridine / dichloromethane / 3 h / 0 - 20 °C

3: C₃₄H₃₁F₆N₃O₃ / dichloromethane / 1 h / 0 °C

With pyridine; thionyl chloride; C₃₄H₃₁F₆N₃O₃; triethylamine; In dichloromethane;
DOI:10.1021/ol401595g