4--α-phenyl-1-piperidinebutanol

Base Information

Chemical Name:4--α-phenyl-1-piperidinebutanol
CAS No.:117023-04-8
Molecular Formula:C₂₈H₃₁F₂NO₂
Molecular Weight:451.556
Hs Code.:

4-<bis(4-fluorophenyl)hydroxymethyl>-α-phenyl-1-piperidinebutanol

Synonyms:4--α-phenyl-1-piperidinebutanol

Suppliers and Price of 4--α-phenyl-1-piperidinebutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4--α-phenyl-1-piperidinebutanol

Chemical Property:

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Technology Process of 4--α-phenyl-1-piperidinebutanol

There total 7 articles about 4--α-phenyl-1-piperidinebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 117023-02-6
4-<4--1-piperidinyl>-1-phenyl-1-butanone

: 117023-04-8
4--α-phenyl-1-piperidinebutanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-04-8
4--α-phenyl-1-piperidinebutanol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 70 percent / Na₂CO₃, KI / butan-1-ol / Heating

4: 72 percent / 1 N HCl / methanol / 96 h / Ambient temperature

5: 61 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; butan-1-ol;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 117023-04-8
4--α-phenyl-1-piperidinebutanol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 70 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 72 percent / 1 N HCl / methanol / 96 h / Ambient temperature

4: 61 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; butan-1-ol;
DOI:10.1021/jm00121a022