3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

Base Information

Chemical Name:3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide
CAS No.:1599530-86-5
Molecular Formula:C₃₀H₂₄F₄N₄O₂
Molecular Weight:548.54
Hs Code.:

Synonyms:3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

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Chemical Property of 3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

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Technology Process of 3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

There total 7 articles about 3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003-21-0
5-bromo-N-methylimidazole

: 1599529-29-9
3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

: 1599530-86-5
3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

Guidance literature:: 5-bromo-N-methylimidazole; With ethylmagnesium chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.35h; Molecular sieve; Inert atmosphere;

3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide; In tetrahydrofuran; dichloromethane; at 20 - 40 ℃; for 13h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1599530-86-5
3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.02 h / 20 °C

2.1: dimethyl sulfoxide / 0.02 h / 100 °C

2.2: 3 h / 130 °C

3.1: ethylmagnesium chloride / dichloromethane; tetrahydrofuran / 0.35 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 13 h / 20 - 40 °C / Inert atmosphere

3.3: 20 °C

With ethylmagnesium chloride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 227609-88-3
4-fluoro-3-iodobenzaldehyde

: 1599530-86-5
3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.11 h / 20 °C / Cooling with acetone-dry ice; Inert atmosphere

1.2: 0.54 h / Cooling with acetone-dry ice; Inert atmosphere

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; potassium bromide; sodium hydrogencarbonate / dichloromethane; water / 0.42 h / Cooling with ice

3.1: ammonia / dimethyl sulfoxide / 2.01 h / 100 °C / Sealed tube

4.1: dimethyl sulfoxide / 0.02 h / 100 °C

4.2: 3 h / 130 °C

5.1: ethylmagnesium chloride / dichloromethane; tetrahydrofuran / 0.35 h / 20 °C / Molecular sieve; Inert atmosphere

5.2: 13 h / 20 - 40 °C / Inert atmosphere

5.3: 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; ethylmagnesium chloride; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;